Preparation and Evaluation of Lamivudine Microspheres Using Various Cellulose Polymers

The present study was planed to prepare microspheres for sustained release of Lamivudine using various cellulose polymers such as Ethyl cellulose, Cellulose acetate phthalate, cellulose acetate by employing solvent evaporation technique. Microspheres were characterized for the particle size distribution, wall thickness by scanning electron microscopy (SEM), angle of repose, drug content, bulk density, entrapment efficiency and in vitro dissolution studies. Drug excepients compatibility was determined by FTIR and DTA. Accelerated stability studies were also carried out following ICH Guidelines. SEM shows that microspheres were found spherical in shape and free flowing. The entrapment efficiency and wall thickness was found in between 68.85%&42.88%, 120.28μ & 72.32μ respectively. The drug release was extended maximum up to 12 hr with ethyl cellulose .FTIR and DSC results showed Lamivudine was compatible with excepients .The curve fitting data shows that the drug release followed first order kinetics, higuchi’s and peppa’s plots stated non-fickian diffusion controlled.